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KMID : 0381120110330040327
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Genes and Genomics
2011 Volume.33 No. 4 p.327 ~ p.333
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Lack of association between FOS polymorphisms and clearance of HBV infection as well as HCC occurrence
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Park Tae-Joon
Kim Jeong-Hyun
Park Byung-Lae
Bae Joon-Seol
Cheong Hyun-Sub
Pasaje Charisse Flerida A.
Lee Hyo-Suk
Kim Yoon-Jun
Shin Hyoung-Doo
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Abstract
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Human v-Fos Finuel-Biskis-Jinkins (FBJ) murine osteosarcoma viral oncogene homolog (FOS) is located in 14q24.3. The FOS protein is a constituent of the activating protein-1 (AP-1) and its increased expression in the hepatocellular carcinoma (HCC) have been reported. In this study, the association of FOS polymorphisms with the HBV infection and HCC occurrence were evaluated in Korean patients. After re-sequencing in 24 unrelated healthy individuals, two common single nucleotide polymorphisms (SNPs) in regulatory regions that were selected based on linkage disequilibrium were genotyped in a total of 1,093 Korean subjects including 656 HBV chronic carriers, who were further stratified into chronic hepatitis/liver cirrhosis (CH/LC, n = 339) and HCC (n = 317) groups, and 437 spontaneously recovered (SR) controls. Logistic regression and Cox relative hazard analysis showed no significant association of regulatory polymorphisms and haplotypes in FOS with HBV clearance and HCC development (P > 0.05, respectively).
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KEYWORD
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Hepatitis B virus, Hepatocellular carcinoma, FOS, Single nucleotide polymorphism
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